Journal article
Creatine metabolism in female reproduction, pregnancy and newborn health
AM Muccini, NT Tran, DL de Guingand, M Philip, PAD Gatta, R Galinsky, LS Sherman, MA Kelleher, KR Palmer, MJ Berry, DW Walker, RJ Snow, SJ Ellery
Nutrients | MDPI | Published : 2021
DOI: 10.3390/nu13020490
Open access
Abstract
Creatine metabolism is an important component of cellular energy homeostasis. Via the creatine kinase circuit, creatine derived from our diet or synthesized endogenously provides spatial and temporal maintenance of intracellular adenosine triphosphate (ATP) production; this is particularly important for cells with high or fluctuating energy demands. The use of this circuit by tissues within the female reproductive system, as well as the placenta and the developing fetus during pregnancy is apparent throughout the literature, with some studies linking perturbations in creatine metabolism to reduced fertility and poor pregnancy outcomes. Maternal dietary creatine supplementation during pregnan..
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Awarded by Oregon National Primate Research Center
Funding Acknowledgements
At the time of writing, S.J.E. (1125539) and R.G. (1090890) were support by Australian National Health and Medical Research Council (NHMRC) Early Career Fellowships. L.S.S. is supported by the Oregon National Primate Research Centre ONPRC (NIH P51 OD011092). The creatine research program being undertaken by the authors of this narrative review is supported by NHMRC project grants to D.W.W., R.J.S. and S.J.E. (1124493) and R.G. (1164954), the Cerebral Palsy Alliance project grants to S.J.E., D.W.W., R.J.S., L.S.S., M.K. and M.J.B. (PG2715 and PG20518), and the Andrea Logan Trust.