Journal article

Protocols for Reproducible, Increased-Scale Synthesis of Engineered Particles—Bridging the “Upscaling Gap”

Steve Spoljaric, Yi Ju, Frank Caruso

Chemistry of Materials | American Chemical Society (ACS) | Published : 2021

Abstract

Large-scale, reproducible synthesis of particles is key to achieving broader material accessibility and applicability. However, direct scaling of experimental parameters, such as reagent volume, does not always translate to the corresponding product yields and/or material property profiles. This is particularly relevant for particle systems, of which the properties and subsequently quality and application are determined from the synthesis methodology. Herein, large-scale synthesis protocols for the templatedirected assembly of three particle systems used in our laboratory are detailed, and challenges and considerations with the assembly methods are discussed. These particle systems have pote..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by National Health and Medical Research Council Senior Principal Research Fellowship


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) and Melbourne Advanced Microscopy Facility at The University of Melbourne, and the Victorian Node of the Australian National Fabrication Facility (ANFF). Transmission electron microscopy analyses were conducted using the facilities at the Biosciences Microscopy Unit, School of Bioscience, The University of Melbourne. We thank A./Prof. Hirotaka Ejima and Drs Quinn A. Besford, Yutian Ma, Mattias Bjornmalm, Joseph J. Richardson, and Christian Cortez-Jugo for helpful discussions, and Drs Matthew Faria and Aleksandr Kakinen for assistance with editing the video footage.