Journal article

A prospective STudy using invAsive haemodynamic measurements foLLowing catheter ablation for AF and early HFpEF: STALL AF-HFpEF

Hariharan Sugumar, Shane Nanayakkara, Donna Vizi, Leah Wright, David Chieng, Angeline Leet, Justin A Mariani, Aleksandr Voskoboinik, Sandeep Prabhu, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler, David M Kaye, Liang-Han Ling



AIMS: The impact of atrial fibrillation (AF) ablation in early heart failure with preserved ejection fraction (HFpEF) is unknown. Our aim was to determine the impact of AF ablation on symptoms and exercise haemodynamic parameters of early HFpEF. METHODS AND RESULTS: Symptomatic AF patients referred for index AF ablation with ejection fraction ≥50% underwent baseline quality of life questionnaires, echocardiography, cardiac magnetic resonance imaging, exercise right heart catheterisation (exRHC), and brain natriuretic peptide (BNP) testing. HFpEF was defined by resting pulmonary capillary wedge pressure (PCWP) ≥15 mmHg or peak exercise PCWP ≥25 mmHg. Patients with HFpEF were offered AF ablati..

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Funding Acknowledgements

S.P. received grants for fellowship support from Boston Scientific and grants for fellowship support from Abbott, outside the submitted work. L.H.L. received grants from Abbott to support cost of investigations during the study. Abbott was not involved in the conception, conduct, data collection, data analysis or manuscript preparation. All other authors have nothing to disclose.