Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Grants

Funding Acknowledgements

This study presents independent research funded by multiple agencies. The funding sources had no role in the study design, data collection, analysis, and interpretation of the data. The views expressed in the manuscript are those of the authors and do not necessarily represent those of any of the funding agencies. Dr. Dima received funding from the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, the Psychiatry Research Trust and 2014 NARSAD Young Investigator Award. Dr. Frangou received support from the National Institutes of Health (R01 MH104284, R01MH113619, R01 MH116147), the European Community's Seventh Framework Programme (FP7/2007-2013) (grant agreement n degrees 602450). This work was supported in part through the computational resources and staff expertise provided by Scientific Computing at the Icahn School of Medicine at Mount Sinai, USA. Dr. Agartz was supported by the Swedish Research Council (grant numbers: 521-2014-3487 and 2017-00949). Dr. Alnaes was supported by the South Eastern Norway Regional Health Authority (grant number: 2019107). Dr. O Andreasen was supported by the Research Council of Norway (grant number: 223273) and South-Eastern Norway Health Authority (grant number: 2017-112). Dr. Cervenka was supported by the Swedish Research Council (grant number 523-2014-3467). Dr. Crespo-Facorro was supported by the IDIVAL Neuroimaging Unit for imaging acquisition; Instituto de Salud Carlos III (grant numbers: PI020499, PI050427, PI060507, PI14/00639 and PI14/00918) and the Fundacion Instituto de Investigacion Marques de Valdecilla (grant numbers: NCT0235832, NCT02534363, and API07/011). Dr. Gur was supported by the National Institute of Mental Health (grant numbers: R01MH042191 and R01MH117014). Dr. James was supported by the Medical Research Council (grant no G0500092). Dr. Saykin received support from U.S. National Institutes of Health grants R01 AG19771, P30 AG10133 and R01 CA101318. Dr. Thompson, Dr. Jahanshad, Dr. Wright, Dr. Medland, Dr. O Andreasen, Dr. Rinker, Dr. Schmaal, Dr. Veltam, Dr. van Erp, and D.P.H. were supported in part by a Consortium grant (U54 EB020403 to P.M.T.) from the NIH Institutes contributing to the Big Data to Knowledge (BD2K) Initiative. FBIRN sample: Data collection and analysis was supported by the National Center for Research Resources at the National Institutes of Health (grant numbers: NIH 1 U24 RR021992 (Function Biomedical Informatics Research Network) and NIH 1 U24 RR025736-01 (Biomedical Informatics Research Network Coordinating Center; ). FBIRN data was processed by the UCI High Performance Computing cluster supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1 TR000153. Brainscale: This work was supported by Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO 51.02.061 to H.H., NWO 51.02.062 to D.B., NWO- NIHC Programs of excellence 433-09-220 to H.H., NWO-MagW 480-04-004 to D.B., and NWO/SPI 56-464-14192 to D.B.); FP7 Ideas: European Research Council (ERC-230374 to D.B.); and Universiteit Utrecht (High Potential Grant to H.H.). UMCU-1.5T: This study is partially funded through the Geestkracht Programme of the Dutch Health Research Council (Zon-Mw, grant No 10-000-1001), and matching funds from participating pharmaceutical companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and universities and mental health care organizations (Amsterdam: Academic Psychiatric Centre of the Academic Medical Center and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen, Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University Medical Center Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius Dordrecht and Parnassia psycho-medical center The Hague. Maastricht: Maastricht University Medical Centre and the mental health institutions: GGzE, GGZ Breburg, GGZ Oost-Brabant, Vincent van Gogh voor Geestelijke Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Utrecht: University Medical Center Utrecht and the mental health institutions Altrecht, GGZ Centraal and Delta.). UMCU-3T: This study was supported by NIMH grant number: R01 MH090553 (to RAO). The NIMH had no further role in study design, in the collection, analysis and interpretation of the data, in the writing of the report, and in the decision to submit the paper for publication. Netherlands Twin Register: Funding was obtained from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organization for Health Research and Development (ZonMW) grants 904-61-090, 985-10-002, 912-10-020, 904-61-193,480-04-004, 463-06-001, 451-04-034, 400-05-717, 400-07-080, 31160008, 016-115-035, 481-08-011, 056-32-010, 911-09-032, 024-001-003, 480-15-001/674, Center for Medical Systems Biology (CSMB, NWO Genomics), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL, 184.021.007 and 184.033.111); Spinozapremie (NWO- 56-464-14192), and the Neuroscience Amsterdam research institute (former NCA). The BIG database, established in Nijmegen in 2007, is now part of Cognomics, a joint initiative by researchers of the Donders Centre for Cognitive Neuroimaging, the Human Genetics and Cognitive Neuroscience departments of the Radboud University Medical Centre, and the Max Planck Institute for Psycholinguistics. The Cognomics Initiative is supported by the participating departments and centers and by external grants, including grants from the Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL) and the Hersenstichting Nederland. The authors also acknowledge grants supporting their work from the Netherlands Organization for Scientific Research (NWO), that is, the NWO Brain & Cognition Excellence Program (grant 433-09-229), the Vici Innovation Program (grant 016-130-669 to BF) and #91619115. Additional support is received from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreements n degrees 602805 (Aggressotype), n degrees 603016 (MATRICS), n degrees 602450 (IMAGEMEND), and n degrees 278948 (TACTICS), and from the European Community's Horizon 2020 Programme (H2020/2014-2020) under grant agreements n degrees 643051 (MiND) and n degrees 667302 (CoCA).Betula sample: Data collection for the BETULA sample was supported by a grant from Knut and Alice Wallenberg Foundation (KAW); the Freesurfer segmentations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) at HPC2N in Umea, Sweden. Indiana sample: This sample was supported in part by grants to BCM from Siemens Medical Solutions, from the members of the Partnership for Pediatric Epilepsy Research, which includes the American Epilepsy Society, the Epilepsy Foundation, the Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures (F.A.C.E.S.), and Parents Against Childhood Epilepsy (P.A.C.E.), from the Indiana State Department of Health Spinal Cord and Brain Injury Fund Research Grant Program, and by a Project Development Team within the ICTSI NIH/NCRR Grant Number RR025761. MHRC study: It was supported in part by RFBR grant 20-013-00748. PING study: Data collection and sharing for the Pediatric Imaging, Neurocognition and Genetics (PING) Study (National Institutes of Health Grant RC2DA029475) were funded by the National Institute on Drug Abuse and the Eunice Kennedy Shriver National Institute of Child Health & Human Development. A full list of PING investigators is at . QTIM sample: The authors are grateful to the twins for their generosity of time and willingness to participate in our study and thank the many research assistants, radiographers, and other staff at QIMR Berghofer Medical Research Institute and the Centre for Advanced Imaging, University of Queensland. QTIM was funded by the Australian National Health and Medical Research Council (Project Grants No. 496682 and 1009064) and US National Institute of Child Health and Human Development (RO1HD050735). Lachlan Strike was supported by a University of Queensland PhD scholarship. Study of Health in Pomerania (SHIP): this is part of the Community Medicine Research net (CMR) (http://www.medizin.uni-greifswald.de/icm) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. This study was further supported by the DZHK (German Centre for Cardiovascular Research), the German Centre of Neurodegenerative Diseases (DZNE) and the EU-JPND Funding for BRIDGET (FKZ:01ED1615). TOP study: this was supported by the European Community's Seventh Framework Programme (FP7/2007-2013), grant agreement n degrees 602450. The Southern and Eastern Norway Regional Health Authority supported Lars T. Westlye (grant no. 2014-097) and STROKEMRI (grant no. 2013-054). HUBIN sample: HUBIN was supported by the Swedish Research Council (K2007-62X-15077-04-1, K2008-62P-20597-01-3, K2010-62X-15078-07-2, K2012-61X-15078-09-3), the regional agreement on medical training and clinical research between Stockholm County Council, and the Karolinska Institutet, and the Knut and Alice Wallenberg Foundation. The BIG database: this was established in Nijmegen in 2007, is now part of Cognomics, a joint initiative by researchers of the Donders Centre for Cognitive Neuroimaging, the Human Genetics and Cognitive Neuroscience departments of the Radboud university medical centre, and the Max Planck Institute for Psycholinguistics.The Cognomics Initiative is supported by the participating departments and centres and by external grants, including grants from the Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL) and the Hersenstichting Nederland. The authors also acknowledge grants supporting their work from the Netherlands Organization for Scientific Research (NWO), that is, the NWO Brain & Cognition Excellence Program (grant 433-09-229), the Vici Innovation Program (grant 016-130-669 to BF) and #91619115. Additional support is received from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreements n degrees 602805 (Aggressotype), n degrees 603016 (MATRICS), n degrees 602450 (IMAGEMEND), and n degrees 278948 (TACTICS), and from the European Community's Horizon 2020 Programme (H2020/2014-2020) under grant agreements n degrees 643051 (MiND) and n degrees 667302 (CoCA).