Journal article
Long-term outcomes of warfarin versus aspirin after Fontan surgery
C Attard, PT Monagle, Y d'Udekem, MT Mackay, J Briody, R Cordina, EB Hassan, P Simm, K Rice, V Ignjatovic, S Mandelstam, C Munns, T Gentles, L Grigg, D Winlaw, JYM Yang
Journal of Thoracic and Cardiovascular Surgery | Published : 2021
Abstract
Objectives: Because of the nature of the Fontan physiology, patients are at an increased risk of thromboembolic complications. As such, warfarin or aspirin is generally prescribed lifelong for thromboprophylaxis. This study aimed to compare long-term rates of cerebrovascular injury, thrombosis, bleeding, bone mineral density, and quality of life in people living with Fontan circulation receiving warfarin compared with aspirin. Methods: This was a multicenter study of a selected cohort from the Australia and New Zealand Fontan population. Participants underwent cerebral magnetic resonance imaging to detect the presence of cerebrovascular injury (n = 84) and dual-energy X-ray absorptiometry to..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
National Health and Medical Research Council (NHMRC) Grant APP1065794: Functional Outcomes After Fontan Surgery. C.A. was supported through an NHMRC postgraduate scholarship. Y.d'U. is a Clinician Practitioner Fellow of the NHMRC (1082186). Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.