Journal article

Long-term outcomes of warfarin versus aspirin after Fontan surgery

Chantal Attard, Paul T Monagle, Yves d'Udekem, Mark T Mackay, Julie Briody, Rachael Cordina, Ebrahim Bani Hassan, Peter Simm, Kathryn Rice, Vera Ignjatovic

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | MOSBY-ELSEVIER | Published : 2021

Abstract

OBJECTIVES: Because of the nature of the Fontan physiology, patients are at an increased risk of thromboembolic complications. As such, warfarin or aspirin is generally prescribed lifelong for thromboprophylaxis. This study aimed to compare long-term rates of cerebrovascular injury, thrombosis, bleeding, bone mineral density, and quality of life in people living with Fontan circulation receiving warfarin compared with aspirin. METHODS: This was a multicenter study of a selected cohort from the Australia and New Zealand Fontan population. Participants underwent cerebral magnetic resonance imaging to detect the presence of cerebrovascular injury (n = 84) and dual-energy X-ray absorptiometry to..

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