Journal article

Lactic acid-containing products for bacterial vaginosis and their impact on the vaginal microbiota: A systematic review

Erica L Plummer, Catriona S Bradshaw, Michelle Doyle, Christopher K Fairley, Gerald L Murray, Deborah Bateson, Lindi Masson, Josephine Slifirski, Gilda Tachedjian, Lenka A Vodstrcil

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2021

Abstract

OBJECTIVE: The vaginal microbiota in bacterial vaginosis (BV) typically has low abundance of lactic acid producing lactobacilli. Lactic acid has properties that may make it effective for treating BV and/or restoring an optimal lactobacillus-dominated vaginal microbiota. We conducted a systematic review to describe the effect of intravaginal lactic acid-containing products on BV cure, and their impact on vaginal microbiota composition (PROSPERO registration: CRD42018115982). METHODS: PubMed, Embase and OVID were searched from inception to November 2019 to identify eligible studies. Included studies evaluated an intravaginal lactic acid-containing product and reported BV cure using established..

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Grants

Awarded by Australian NHMRC


Awarded by NHMRC


Awarded by Medical Research Future Fund (MRFF) Frontier in Health and Medical Research Program Stage One


Funding Acknowledgements

ELP was supported by an Australian Government Research Training Program (RTP) Scholarship. CSB and CKF are supported by an Australian NHMRC Leadership Investigator Grant (GNT1173361 and GNT1172900, respectively). GT was supported by NHMRC Senior Research Fellowship (GNT1117748) and NHMRC Project Grant (GNT1164982). LAV was supported by NHMRC Project Grant (APP1138165). GT, CSB, CKF, DB are supported by Medical Research Future Fund (MRFF) Frontier in Health and Medical Research Program Stage One (MRFF75913). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.