Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface
Setareh Sianati, Lioba Schroeter, Jessica Richardson, Andy Tay, Shireen R Lamande, Kate Poole
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | FRONTIERS MEDIA SA | Published : 2021
Ion channels activated by mechanical inputs are important force sensing molecules in a wide array of mammalian cells and tissues. The transient receptor potential channel, TRPV4, is a polymodal, nonselective cation channel that can be activated by mechanical inputs but only if stimuli are applied directly at the interface between cells and their substrate, making this molecule a context-dependent force sensor. However, it remains unclear how TRPV4 is activated by mechanical inputs at the cell-substrate interface, which cell intrinsic and cell extrinsic parameters might modulate the mechanical activation of the channel and how mechanical activation differs from TRPV4 gating in response to oth..View full abstract
Awarded by NHMRC Australia
This project was supported by Project grants from the NHMRC Australia: APP1122104 (awarded to KP) and APP1144807 (awarded to SL and KP), by an Australian Government RTP and a UNSW School of Medical Sciences funded scholarship to JR and an Endeavor Research Fellowship from the Australian Government for AT and the Victorian Government's Operational Infrastructure Support Program for SL.