Journal article

Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface

Setareh Sianati, Lioba Schroeter, Jessica Richardson, Andy Tay, Shireen R Lamande, Kate Poole

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

Ion channels activated by mechanical inputs are important force sensing molecules in a wide array of mammalian cells and tissues. The transient receptor potential channel, TRPV4, is a polymodal, nonselective cation channel that can be activated by mechanical inputs but only if stimuli are applied directly at the interface between cells and their substrate, making this molecule a context-dependent force sensor. However, it remains unclear how TRPV4 is activated by mechanical inputs at the cell-substrate interface, which cell intrinsic and cell extrinsic parameters might modulate the mechanical activation of the channel and how mechanical activation differs from TRPV4 gating in response to oth..

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Grants

Awarded by NHMRC Australia


Funding Acknowledgements

This project was supported by Project grants from the NHMRC Australia: APP1122104 (awarded to KP) and APP1144807 (awarded to SL and KP), by an Australian Government RTP and a UNSW School of Medical Sciences funded scholarship to JR and an Endeavor Research Fellowship from the Australian Government for AT and the Victorian Government's Operational Infrastructure Support Program for SL.