Journal article

Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice

Lara M Voglsanger, Justin Read, Sarah S Ch'ng, Cary Zhang, Izel M Eraslan, Laura Gray, Leni R Rivera, Lee D Hamilton, Richard Williams, Andrew L Gundlach, Craig M Smith

Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2021

Abstract

RXFP3 (relaxin-family peptide 3 receptor) is the cognate G-protein-coupled receptor for the neuropeptide, relaxin-3. RXFP3 is expressed widely throughout the brain, including the hypothalamus, where it has been shown to modulate feeding behavior and neuroendocrine activity in rodents. In order to better characterize its potential mechanisms of action, this study determined whether RXFP3 is expressed by dopaminergic neurons within the arcuate nucleus (ARC) and dorsomedial hypothalamus (DMH), in addition to the ventral tegmental area (VTA). Neurons that express RXFP3 were visualized in coronal brain sections from RXFP3-Cre/tdTomato mice, which express the tdTomato fluorophore within RXFP3-posi..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

Grant Sponsor: National Health and Medical Research Council of Australia; Grant number: 1024885 (AG), 1079893 (AG), and 1165801 (AG, CS); Grant Sponsor: Brain and Behavior Research Foundation (USA) NARSAD Independent Investigator Award (AG); Grant Sponsor: Victorian Government Operational Infrastructure Support Programme (Florey); Grant Sponsor: Deakin University School of Medicine and Centre for Molecular and Medical Research Strategic Research Centre (CS).