Journal article

Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men.

Liza O'Donnell, Diane Rebourcet, Laura F Dagley, Raouda Sgaier, Giuseppe Infusini, Peter J O'Shaughnessy, Frederic Chalmel, Daniela Fietz, Wolfgang Weidner, Julien MD Legrand, Robin M Hobbs, Robert I McLachlan, Andrew I Webb, Adrian Pilatz, Thorsten Diemer, Lee B Smith, Peter G Stanton

The FASEB Journal | Published : 2021

Abstract

Sperm develop from puberty in the seminiferous tubules, inside the blood-testis barrier to prevent their recognition as "non-self" by the immune system, and it is widely assumed that human sperm-specific proteins cannot access the circulatory or immune systems. Sperm-specific proteins aberrantly expressed in cancer, known as cancer-testis antigens (CTAs), are often pursued as cancer biomarkers and therapeutic targets based on the assumption they are neoantigens absent from the circulation in healthy men. Here, we identify a wide range of germ cell-derived and sperm-specific proteins, including multiple CTAs, that are selectively deposited by the Sertoli cells of the adult mouse and human sem..

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Grants

Awarded by RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)


Awarded by Department of Health | National Health and Medical Research Council (NHMRC)


Awarded by Medical Research Council Program Grant Award