Journal article

Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study

Vinoomika Chandrasekaran, Julie A Pasco, Amanda L Stuart, Sharon L Brennan-Olsen, Michael Berk, Jason M Hodge, Rasika M Samarasinghe, Lana J Williams

BMC MUSCULOSKELETAL DISORDERS | BMC | Published : 2021

Abstract

BACKGROUND: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. METHODS: Data from 926 men (24-73 yr) and 1070 women (21-94 yr) participating in the Geelong Osteoporosis Study were included. Bone mineral density (BMD, g/cm2) of the PA-spine and total hip was measured using dual-energy X-ray absorptiometry (Lunar). Bone quality was determined using quantitative heel ultrasound (QUS). Anthropometry was conducted and socioeconomic status was determined. Medication and lifestyle information was obtained via questionnaire. Linear regression was used..

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Grants

Awarded by National Health and Medical Research Council (NHMRC, of Australia)


Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Emerging Research Fellowship


Funding Acknowledgements

The study is supported by the National Health and Medical Research Council (NHMRC, of Australia) (GNT1104438). VC is supported by a Deakin University Postgraduate Research Scholarship, SLB-O is supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship (GNT1107510), MB is supported by a NHMRC Senior Principal Research Fellowship (1059660 and 1156072) and LJW is supported by a NHMRC Career Development Fellowship (1064272) and a NHMRC Emerging Research Fellowship (1174060).