Journal article
A Systematic Review and Meta-Analysis on Effects of Bicarbonate Therapy on Kidney Outcomes
S Hultin, C Hood, KL Campbell, ND Toussaint, DW Johnson, SV Badve
Kidney International Reports | Published : 2021
Open access
Abstract
Aim: Preclinical studies suggest treatment of metabolic acidosis may slow chronic kidney disease (CKD) progression. This systematic review aimed to summarize evidence from randomized controlled trials (RCTs) concerning the benefits and risks of bicarbonate therapy on kidney outcomes. Methods: Medline, EMBASE, and Cochrane databases were searched for RCTs with ≥3 months’ follow-up in patients with CKD (estimated glomerular filtration rate [eGFR] ≤60 ml/min per 1.73 m2 and/or proteinuria) comparing the effects of sodium bicarbonate with placebo/no study medication on kidney outcomes. The primary outcome was change from baseline to last measurement in kidney function measured as either eGFR or ..
View full abstractGrants
Funding Acknowledgements
The authors gratefully thank Dr Sinee Disthabanchong (Ramathibodi Hospital, Mahidol University, Bangkok, Thailand) , Dr Donald E. Wesson (Texas A&M College of Medicine, Scott and White Healthcare, Temple, Texas, USA) , Professor Muhammad Yaqoob (William Harvey Research Institute and Barts and the London NHS Trust, London, United Kingdom) , A/Professor Kalani Raphael (University of Utah, Salt Lake City, USA) , and Professor Miles Witham (NIHR Newcastle Biomedical Research Centre, Newcastle University, United Kingdom) for providing requested data. DWJ is supported by an Australian Government National Health and Medical Research Council (NHMRC) Practitioner Fellowship. SVB is supported by a John Chalmers Clinical Research Fellowship with the support of Servier from The George Institute for Global Health, Australia. These supporting organizations/agencies had no role in the design and conduct of the study, analysis and interpretation of the data, review and approval of the manuscript, and decision to submit the manuscript.