Journal article

Evaluation of risk factors for and subsequent mortality from poor graft function (PGF) post allogeneic stem cell transplantation

Ashvind Prabahran, Rachel Koldej, Lynette Chee, Eric Wong, David Ritchie

LEUKEMIA & LYMPHOMA | TAYLOR & FRANCIS LTD | Published : 2021

Abstract

Poor Graft Function (PGF) is defined by multi-lineage cytopenias with complete donor chimerism post allogeneic transplantation, Risk factors for and subsequent mortality from PGF were assessed in our transplant cohort. Non-sibling donor [OR 1.97; 95% CI 1.02-3.70], ICU admission [OR 5.28; 95% CI 2.29-11.88] or blood culture positivity within the first 30 days [OR 1.67; 95% CI 1.07-2.62], grade III-IV acute graft vs host disease (GVHD) [OR 4.082; 95% CI 2.31-7.16] and CMV viremia [OR 2.43; 95% CI 1.53-3.88] and were significantly associated with development of PGF. PGF patients without count recovery had a 2 year OS of 6%. Severe GVHD, thrombocytopenia and anemia portended inferior survival a..

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