Long-term atmospheric exposure to PCB153 and breast cancer risk in a case-control study nested in the French E3N cohort from 1990 to 2011.
Floriane Deygas, Amina Amadou, Thomas Coudon, Lény Grassot, Florian Couvidat, Bertrand Bessagnet, Elodie Faure, Pietro Salizzoni, John Gulliver, Julien Caudeville, Gianluca Severi, Francesca Romana Mancini, Karen Leffondré, Béatrice Fervers, Delphine Praud
Environ Res | Published : 2021
BACKGROUND: Although the genetic and hormonal risk factors of breast cancer are well identified, they cannot fully explain the occurrence of all cases. Epidemiological and experimental studies have suggested that exposure to environmental pollutants, especially those with potential estrogenic properties, as polychlorinated biphenyls (PCBs) may have a role in breast cancer development. Being the most abundantly detected in human tissues and in the environment, congener 153 (PCB153) is widely used in epidemiological studies as indicator for total PCBs exposure. OBJECTIVES: We aimed to estimate the association between cumulative atmospheric exposure to PCB153 and breast cancer risk. METHODS: We..View full abstract