An Updated Review of the Diagnostic Methods in Delayed Drug Hypersensitivity
Ana Copaescu, Andrew Gibson, Yueran Li, Jason A Trubiano, Elizabeth J Phillips
FRONTIERS IN PHARMACOLOGY | FRONTIERS MEDIA SA | Published : 2021
Delayed drug hypersensitivity reactions are clinically diverse reactions that vary from isolated benign skin conditions that remit quickly with no or symptomatic treatment, drug discontinuation or even continued drug treatment, to the other extreme of severe cutaneous adverse reactions (SCARs) that are associated with presumed life-long memory T-cell responses, significant acute and long-term morbidity and mortality. Diagnostic "in clinic" approaches to delayed hypersensitivity reactions have included patch testing (PT), delayed intradermal testing (IDT) and drug challenges for milder reactions. Patch and IDT are, in general, performed no sooner than 4-6 weeks after resolution of the acute r..View full abstract
EP receives support from 1P50GM115305, R21AI139021, 1 R01 HG010863, and 1R01AI152183.