Novel Role of Platelets in Mediating Inflammatory Responses and Ventricular Rupture or Remodeling Following Myocardial Infarction
Yang Liu, Xiao-Ming Gao, Lu Fang, Nicole L Jennings, Yidan Su, Xu Q, Andre L Samson, Helen Kiriazis, Xin-Feng Wang, Leonard Shan, Sharelle A Sturgeon, Robert L Medcalf, Shaun P Jackson, Anthony M Dart, Xiao-Jun Du
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
OBJECTIVE: The goal of this study was to investigate the role of platelets in systemic and cardiac inflammatory responses and the development of postinfarct ventricular complications, as well as the efficacy of antiplatelet interventions. METHODS AND RESULTS: Using a mouse myocardial infarction (MI) model, we determined platelet accumulation and severity of inflammation within the infarcted myocardium by immunohistochemistry and biochemical assays, analyzed peripheral blood platelet-leukocyte conjugation using flow cytometry, and tested antiplatelet interventions, including thienopyridines and platelet depletion. Platelets accumulated within the infarcted region early post-MI and colocalized..View full abstract
This study was funded by grants from the National Health and Medical Research Council of Australia (NHMRC). Dr Jackson is an Australian Fellow and Drs Medcalf, Dart, and Du are NHMRC Fellows.