Journal article

Structural Analysis of Coxsackievirus A7 Reveals Conformational Changes Associated with Uncoating

Jani JT Seitsonen, Shabih Shakeel, Petri Susi, Arun P Pandurangan, Robert S Sinkovits, Heini Hyvonen, Pasi Laurinmaki, Jani Yla-Pelto, Maya Topf, Timo Hyypia, Sarah J Butcher

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2012

Abstract

Coxsackievirus A7 (CAV7) is a rarely detected and poorly characterized serotype of the Enterovirus species Human enterovirus A (HEV-A) within the Picornaviridae family. The CAV7-USSR strain has caused polio-like epidemics and was originally thought to represent the fourth poliovirus type, but later evidence linked this strain to the CAV7-Parker prototype. Another isolate, CAV7-275/58, was also serologically similar to Parker but was noninfectious in a mouse model. Sequencing of the genomic region encoding the capsid proteins of the USSR and 275/58 strains and subsequent comparison with the corresponding amino acid sequences of the Parker strain revealed that the Parker and USSR strains are n..

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Grants

Awarded by NIH


Awarded by Academy of Finland Centre of Excellence Programme in Virus Research


Awarded by Academy of Finland


Awarded by Medical Research Council


Awarded by Human Frontier Science Program


Awarded by MRC


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

R.S.S. thanks Timothy S. Baker for supporting the work through his NIH grants R37 GM-033050 and R01 AI-079095 and gift from the Agouron Foundation. This work was also supported by the Academy of Finland Centre of Excellence Programme in Virus Research (2006-2011; 129684 to S.J.B.), the Academy of Finland (139178 to S.J.B.; 128539 to P.S.; and 122215 to T.H.), the Sigrid Juselius Foundation (S.J.B. and T.H.), the National Graduate School in Informational and Structural Biology (J.J.T.S.), the Helsinki Graduate Program in Biotechnology and Molecular Biology (S.S.), the Medical Research Council Career Development Award (G0600084 to M.T.) and the Human Frontier Science Program (RGY0079/2009-C to M.T.).