Airway smooth muscle cells

Abstract

Airway smooth muscle (ASM) cell complexity is becoming increasingly apparent. Initially considered to be merely a contractile element, it is now known that smooth muscle cells actively regulate their function and microenvironment by producing a range of cytokines and low molecular weight products in addition to extracellular matrix. Growth and proliferation of smooth muscle cells within the airway is also recognised as a component of airway pathology, especially in asthma. This chapter is intended to provide an overview of smooth muscle function and to highlight recent advances in areas of active research.