Journal article

Final Results of a Multicenter Phase II Trial with Translational Elements to Investigate the Possible Infective Causes of Ocular Adnexal Marginal Zone B-Cell Lymphoma (OAMZL) with Particular Reference to Chlamydia Species and the Efficacy of Doxycycline As First-Line Lymphoma Treatment (the IELSG#27 TRIAL)

Silvia Govi, Riccardo Dolcetti, Maurilio Ponzoni, Elisa Pasini, Silvia Mappa, Marta Bruno Ventre, Claudio Doglioni, Francesco Bertoni, Francesco Zaja, Carlos Montalban, Caterina Stelitano, Maria Elena Cabrera, Franco Cavalli, Emanuele Zucca, Andrés JM Ferreri

Blood | American Society of Hematology | Published : 2011


Abstract Abstract 267 BACKGROUND: Chlamydophila psittaci (Cp) infection carries a potential pathogenic role in OAMZL and has been detected in tumor tissue of a high proportion of patients (pts), with geographic differences in its prevalence rates. The use of immunohistochemistry, immunofluorescence and electronic microscopy techniques has identified monocyte/macrophage as carriers of Cp in OAMZL, and bacteria eradication with doxycycline (DOXY) has been associated with lymphoma regression in half of pts. Notwithstanding these achievements, clinical and therapeutic knowledge on this association mainly result from retrospective..

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