The Gastric H/K ATPase β Subunit Gene and Transcriptional Pathways in Acid-Secreting Epithelia of the Stomach and Kidney

Abstract

Stomach acid is produced by parietal cells and secreted into the gastric lumen for digestive and protective purposes. The gastric parietal cell has a highly developed acid secretory machinery that can maintain the pH of the gastric lumen at around pH 1 (Forte and Soil, 1993; Sachs et al., 1992; Faller et al., 1993; Rabon and Reuben, 1990). The central role of the gastric H/K ATPase in the secretion of gastric HC1 is undisputed. The protein is located in the membranes of the parietal cell tubulovesicles and secretory canaliculi. The mechanism of action and structure of the gastric H/K ATPase have been extensively reviewed in this volume and elsewhere. The protein is composed of two subunits, ..