Journal article

Complex patterns of circulating fatty acid levels in gestational diabetes mellitus subclasses across pregnancy

Ting Zhang, Wen-Rong Jiang, Yin-Yin Xia, Toby Mansell, Richard Saffery, Richard D Cannon, Jamie De Seymour, Zhen Zou, Ge Xu, Ting-Li Han, Hua Zhang, Philip N Baker

CLINICAL NUTRITION | CHURCHILL LIVINGSTONE | Published : 2021

Abstract

BACKGROUND & AIMS: To investigate the relationship between maternal serum fatty acid levels and gestational diabetes mellitus (GDM) subtypes across pregnancy. METHODS: A total of 680 singleton mothers enrolled in the Complex Lipids in Mothers and Babies (CLIMB) study in Chongqing, China were included. Clinical information and serum samples were collected at gestational weeks (GWs) 11-14, 22-28, and 32-34. 75 g Oral Glucose Tolerance Test (OGTT) was conducted at GW 24-28 and GDM subtypes divided into three groups using International Association of Diabetes and Pregnancy Study Group (IADPSG) guidelines criteria: elevated fasting plasma glucose (FPG group; n = 59); 1-h and/or 2-h post-load gluc..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by 111 Project


Awarded by National Key Research and Development Program of Reproductive Health & Major Birth Defects Control and Prevention


Awarded by Chongqing Science and Technology Commission


Awarded by Chongqing Health Commission


Funding Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81971406, 81771607, 81871185, 81961128004), The 111 Project (Yuwaizhuan (2016)32), The National Key Research and Development Program of Reproductive Health & Major Birth DefectsControl andPrevention(2016YFC1000407), Chongqing Health Commission (2017ZDXM008, 2018ZDXM024) and Chongqing Science and Technology Commission (cstc2017jcyjBX0060, cstc2018jcyjAX0359), The Joint International Research Laboratory of Reproduction andDevelopment. The CLIMB study was also supported inpart by the New Zealand Primary Growth Partnership post farm gate dairy programme, funded by Fonterra Co-Operative Group, New Zealand and the New Zealand Ministry for Primary Industries. The design and conception of the study was led by the principal investigators. The funders had no role in data collection and analysis or decision to publish.