Hippocampal atrophy is independent of amyloid status 3 years after ischemic stroke

Abstract

AbstractBackgroundHippocampal atrophy, long thought to be an imaging signature of Alzheimer’s disease, is seen in a range of neurodegenerative disorders, and in association with vascular risk factors in people without dementia. We examined hippocampal volume (HV) in a group of ischemic stroke patients who participated in an amyloid PET imaging study 3 years after their stroke. Given the complex interactions between normal brain aging, vascular risk factors and brain histopathology, we hypothesized that there would be no association between HV and amyloid status.MethodThe Cognition And Neocortical Volume After Stroke (CANVAS) study is an observational cohort study of 135 patients with ischemi..