80 The microbiome in early cystic fibrosis lung disease: A longitudinal analysis

Abstract

ObjectivesThe evolution of the respiratory microbiome in CF and its contribution to the development of lung disease is yet to be characterised. The few longitudinal studies in older patients suggest a decrease in microbial diversity over time, possibly occurring in conjunction with declining pulmonary function.This study describes the lower airway microbiome in CF and its evolution in early childhood. We aim to assess the correlation between the microbiome, traditional culture-based microbiology and inflammatory status, and to examine the impact of the early lung microbiome on pulmonary function at six years of age.MethodsSerial surveillance bronchoscopies were performed on newly diagnosed i..