Journal article
Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: A large single-centre study
CHR Choi, I Al Bakir, NSJ Ding, GH Lee, A Askari, J Warusavitarne, M Moorghen, A Humphries, A Ignjatovic-Wilson, S Thomas-Gibson, BP Saunders, MD Rutter, TA Graham, AL Hart
Gut | BMJ PUBLISHING GROUP | Published : 2019
Open access
Abstract
Objective Ulcerative colitis (UC) is a dynamic disease with its severity continuously changing over time. We hypothesised that the risk of colorectal neoplasia (CRN) in UC closely follows an actuarial accumulative inflammatory burden, which is inadequately represented by current risk stratification strategies. Design This was a retrospective single-centre study. Patients with extensive UC who were under colonoscopic surveillance between 2003 and 2012 were studied. Each surveillance episode was scored for a severity of microscopic inflammation (0=no activity; 1=mild; 2=moderate; 3=severe activity). The cumulative inflammatory burden (CIB) was defined as sum of: average score between each pair..
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Awarded by Medical Research Council
Funding Acknowledgements
The authors acknowledge funding from Cancer Research UK (A19771 to TAG), the Wellcome Trust (202778/Z/16/Z to TAG) and the Barts Charity (472/2300 to TAG). C-HRC was funded by a studentship from the Derek Willoughby Fund for Inflammatory Research, and IAB is funded by a studentship from the UK Medical Research Council.