Journal article

Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm

JP Segal, NS Ding, G Worley, S Mclaughlin, S Preston, OD Faiz, SK Clark, AL Hart

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | WILEY | Published : 2017

Abstract

BACKGROUND: Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is considered the procedure of choice in patients with ulcerative colitis (UC) refractory to medical therapy. The incidence of pouchitis is 40% at 5 years. Ten to 15% of patients with pouchitis experience chronic pouchitis. AIM: To determine the efficacy of medical therapies for the treatment of chronic refractory pouchitis in patients undergoing IPAA for UC. METHODS: A systematic computer-assisted search of the on-line bibliographic database MEDLINE and EMBASE was performed between 1966 and February 2016. All original studies reporting remission rates following medical treatment for chronic pouchitis were inclu..

View full abstract

University of Melbourne Researchers