Journal article
Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm
JP Segal, NS Ding, G Worley, S Mclaughlin, S Preston, OD Faiz, SK Clark, AL Hart
ALIMENTARY PHARMACOLOGY & THERAPEUTICS | WILEY | Published : 2017
DOI: 10.1111/apt.13905
Abstract
BACKGROUND: Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is considered the procedure of choice in patients with ulcerative colitis (UC) refractory to medical therapy. The incidence of pouchitis is 40% at 5 years. Ten to 15% of patients with pouchitis experience chronic pouchitis. AIM: To determine the efficacy of medical therapies for the treatment of chronic refractory pouchitis in patients undergoing IPAA for UC. METHODS: A systematic computer-assisted search of the on-line bibliographic database MEDLINE and EMBASE was performed between 1966 and February 2016. All original studies reporting remission rates following medical treatment for chronic pouchitis were inclu..
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