Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study
Shuai Li, Xinyang Hua
BMC MEDICAL GENOMICS | BMC | Published : 2021
BACKGROUND: Lifestyle factors including obesity and smoking are suggested to be correlated with increased risk of COVID-19 severe illness or related death. However, whether these relationships are causal is not well known; neither for the relationships between COVID-19 severe illness and other common lifestyle factors, such as physical activity and alcohol consumption. METHODS: Genome-wide significant genetic variants associated with body mass index (BMI), lifetime smoking, physical activity and alcohol consumption identified by large-scale genome-wide association studies (GWAS) of up to 941,280 individuals were selected as instrumental variables. Summary statistics of the genetic variants o..View full abstract
Awarded by Victorian Cancer Agency Early Career Research Fellowship
This work and SL are supported by the Victorian Cancer Agency Early Career Research Fellowship (ID: ECRF19020). The funder has no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.