Thesis / Dissertation

Exploring Efficient Generation of InsulinProducing Cells from iPSCs, to Enhance Cell Therapy for Type I Diabetes

Tianyu Wang, Edouard Stanley (ed.)

Published : 2020

Abstract

Type I Diabetes Mellitus (TIDM) is one of the immune disorders and results from the loss of cells that make insulin (INS), a hormone that regulates the level and availability of glucose within the body. The most common treatment is exogenous insulin therapy which involves regular insulin injections or the use of an insulin pump. However, this treatment is imperfect and cumbersome, driving researchers to find more effective methods to control blood glucose levels. One potential treatment would involve making INS producing beta cells using pluripotent stem cells and then using these manufactured cells as a beta cell replacement therapy. Making insulin-producing cells in the laboratory involve..

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