Midlife Leukocyte Telomere Length as an Indicator for Handgrip Strength in Late Life.
Xuling Chang, Kevin Yiqiang Chua, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Rajkumar Dorajoo
The Journals of Gerontology Series A | Published : 2021
BACKGROUND: Telomere attrition has been proposed as a hallmark of aging. We previously reported on the association between blood leukocyte telomere length (LTL) at midlife and risk of chronic diseases and mortality. METHODS: In this study, we investigated the effect of midlife LTL and genetic proxies on 5 markers of aging outcomes, namely handgrip strength, timed up-and-go (TUG), Singapore-modified Mini-Mental State Examination (SM-MMSE) scores, anxiety, and depression indices, measured after a median 20-year follow-up in the Singapore Chinese Health Study (N = 9581). RESULTS: We observed a significant association between midlife LTL and handgrip strength later in life (p = .004, padjust = ...View full abstract