Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population.
Xuling Chang, Rajkumar Dorajoo, Yi Han, Ling Wang, Jianjun Liu, Chiea-Chuen Khor, Adrian F Low, Mark Yan-Yee Chan, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Chew-Kiat Heng
Molecular Genetics and Genomic Medicine | Published : 2020
BACKGROUND: Haptoglobin (Hp) is a plasma protein with strong anti-inflammation and antioxidant activities. Its plasma level is known to be inversely associated with many inflammatory diseases, including cardiovascular diseases. However, the association of HP genetic variants with coronary artery disease (CAD) severity/mortality, and how they interact with common CAD risk factors are largely unknown. METHODS: We conducted the analysis in a Singaporean Chinese CAD population with Gensini severity scores (N = 582) and subsequently evaluated the significant findings in an independent cohort with cardiovascular mortality (excluding stroke) as outcome (917 cases and 19,093 controls). CAD risk fact..View full abstract