Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.
Jaana A Hartiala, Yi Han, Qiong Jia, James R Hilser, Pin Huang, Janet Gukasyan, William S Schwartzman, Zhiheng Cai, Subarna Biswas, David-Alexandre Trégouët, Nicholas L Smith, undefined INVENT Consortium, undefined CHARGE Consortium Hemostasis Working Group, undefined GENIUS-CHD Consortium, Marcus Seldin, Calvin Pan, Margarete Mehrabian, Aldons J Lusis, Peter Bazeley, Yan V Sun Show all
European Heart Journal | Published : 2021
AIMS: While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish atherosclerosis may be distinct from those that predispose to vulnerable plaques and thrombus formation. METHODS AND RESULTS: We carried out a genome-wide association study for MI in the UK Biobank (n∼472 000), followed by a meta-analysis with summary statistics from the CARDIoGRAMplusC4D Consortium (n∼167 000). Multiple independent replication analyses and functional approaches were used to prioritize loci and evaluate positional candidate genes...View full abstract
Awarded by NIEHS NIH HHS
Awarded by NHLBI NIH HHS
Awarded by NIMHD NIH HHS
Awarded by British Heart Foundation