Journal article

Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

Melanie R Neeland, Samantha Bannister, Vanessa Clifford, Kate Dohle, Kim Mulholland, Philip Sutton, Nigel Curtis, Andrew C Steer, David P Burgner, Nigel W Crawford, Shidan Tosif, Richard Saffery

NATURE COMMUNICATIONS | NATURE PORTFOLIO | Published : 2021

Abstract

Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report acute and convalescent innate immune responses in 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We find clinically mild SARS-CoV-2 infection in children is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells and natural killer cells during the acute phase. In contrast, SARS-CoV-2-infected adults show reduced proportions of non-classical monocytes only. We also observe increased proportions o..

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Grants

Funding Acknowledgements

The FFX study has Australian Commonwealth government support for identification of positive samples and database management. MRN is supported by a Melbourne Children's LifeCourse Fellowship. DPB is supported by an NHMRC Investigator Grant. PS is supported by a DHB Foundation Fellowship.