Journal article

Severe respiratory syncytial virus disease in preterm infants: a case of innate immaturity

Jeremy Anderson, Lien Anh Ha Do, Danielle Wurzel, Zheng Quan Toh, Kim Mulholland, Daniel G Pellicci, Paul Licciardi

THORAX | BMJ PUBLISHING GROUP | Published : 2021

Abstract

Respiratory syncytial virus (RSV) is the most common viral pathogen associated with acute lower respiratory tract infection (LRTI) in children under 5 years of age. Severe RSV disease is associated with the development of chronic respiratory complications such as recurrent wheezing and asthma. A common risk factor for developing severe RSV disease is premature gestation and this is largely due to an immature innate immune system. This increases susceptibility to RSV since the innate immune system is less able to protect against pathogens at a time when adaptive immunity has not fully developed. This review focuses on comparing different aspects of innate immunity between preterm and term inf..

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Grants

Funding Acknowledgements

PVL is supported by an Australian National Health and Medical Research Council (NHMRC) Career Development Fellowship. DGP is supported by a CSL Centenary Fellowship. JA is supported by an Australian Postgraduate Award Scholarship. The support of the Victorian Government's Operational Infrastructure Support Program is acknowledged. Figures were created using BioRender.com.