Regulatory Factors in Secretory Phase Uterine Washings Are Derived from Endometrial Epithelial Cells and Can Be Selectively Altered by hCG, Providing a Means to Enhance Receptivity.

Abstract

Successful blastocyst implantation requires a synchronized dialogue between a receptive endometrium and a functional blastocyst. This is mediated in part by endometrial cytokines/growth factors secreted by glandular epithelium into the uterine cavity, which may contribute to endometrial receptivity and also support the blastocyst during implantation. Recent evidence suggests that blastocyst-derived hCG may further influence the endometrial milieu in conception cycles to enhance receptivity. The inability to achieve endometrial receptivity results in infertility in women and contributes to the failure of reproductive technologies. However, there is currently no robust test for endometrial rec..