Journal article

Cortical expression of the RAPGEF1 gene in schizophrenia: investigating regional differences and suicide

Andrea Gogos, Jeehae Sun, Madhara Udawela, Andrew Gibbons, Maarten van den Buuse, Elizabeth Scarr, Brian Dean

PSYCHIATRY RESEARCH | ELSEVIER IRELAND LTD | Published : 2021

Abstract

Rap guanine nucleotide exchange factor 1 (RAPGEF1) is involved in cell adhesion and neuronal migration. Previously we found lower RAPGEF1 mRNA levels in Brodmann's area (BA) 9 in subjects with schizophrenia compared to controls. This study aimed to determine whether RAPGEF1 expression was altered in other brain regions implicated in schizophrenia and whether this was associated with suicide. Using qPCR, we measured the levels of RAPGEF1 in post-mortem BA 8 and 44 from 27 subjects with schizophrenia and 26 non-psychiatric control subjects. To address the effect of antipsychotic treatments, Rapgef1 mRNA levels were measured in the cortex from rats treated with typical antipsychotic drugs. Ther..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This research was funded by the National Health and Medical Research Council of Australia (AG CDF ID1108098). The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant. The authors gratefully acknowledge the Victorian Brain Bank as the source of the human postmortem tissue used in this study and Geoff Pavey for his technical assistance and curation of the human brain tissue.