Journal article

Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts

Jason Rosado, Michael T White, Rhea J Longley, Marcus Lacerda, Wuelton Monteiro, Jessica Brewster, Jetsumon Sattabongkot, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M Vinetz, Dionicia Gamboa, Ivo Mueller

PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2021

Abstract

BACKGROUND: Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody responses in naturally infected people from endemic settings. To address this question, we studied IgG responses to novel serological exposure markers (SEMs) of P. vivax in three settings with different transmission intensity. METHODOLOGY: We validated a panel of 34 SEMs in a Peruvian cohort with up to three years' longitudinal follow-up using a multiplex platform and compared results to data from cohorts in Thailand and Brazil. Linear regression models were used to characterize the association between..

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Grants

Awarded by National Health and Medical Research Council Australia


Awarded by Global Health Innovative Technology Fund


Awarded by National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID)


Awarded by Fundacao de Amparo a Pesquisa do Estado do Amazonas-FAPEAM


Awarded by NHMRC Early Career Investigator Fellowship



Funding Acknowledgements

This work was supported by National Health and Medical Research Council Australia grants 1092789, 1134989 and 1043345 to IM (https://www.nhmrc.gov.au/), the Global Health Innovative Technology Fund grant T2015-142 to IM (https://www.ghitfund.org/), National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID) U19AI089681 to JMV (https://www.niaid.nih.gov).This work has been supported by FIND with funding from the Australian and British governments. The Brazilian team was partly funded by Fundacao de Amparo a Pesquisa do Estado do Amazonas-FAPEAM (PAPAC 005/2019 and Pro-Estado). JR is supported by the Pasteur -Paris University (PPU) International PhD Program. RJL received the Page Betheras Award from WEHI to provide funding for technical support for this project during parental leave. RJL is supported by a NHMRC Early Career Investigator Fellowship (1173210). ML andWM are fellows of the Brazilian National Council for Scientific and Technological Development. MGG is supported by Training Grant 5D43TW007120 (https://www.fic.nih.gov).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.