P511 Early prediction of steroid failure in acute severe ulcerative colitis

Abstract

Acute severe ulcerative colitis (ASUC) is a medical emergency that requires prompt assessment and judicious management. IV corticosteroids are first-line therapy, but a significant proportion who do not improve after 3–7 days require salvage treatment or surgery. Management decisions are conventionally based on the Oxford criteria1 though recent data suggest that an Ulcerative Colitis Endoscopic Index of Severity (UCEIS) >6 and faecal calprotectin (FC) >1000 μg/g at Day 3 are markers of steroid failure. We report the results of a study which examined the association of steroid response with clinical activity, biomarkers and endoscopic findings at admission. A prospective cohort of inpatients..