Cognitive ability and metabolic physical health in first-episode psychosis

Sarah Whitson; Brian O'Donoghue; Robert Hester; Lara Baldwin; Susy Harrigan; Shona Francey; Jessica Graham; Barnaby Nelson; Aswin Ratheesh; Mario Alvarez-Jimenez; Alex Fornito; Christos Pantelis; Hok Pan Yuen; Andrew Thompson; Melissa Kerr; Michael Berk; Stephen J Wood; Patrick McGorry; Kelly Allott

Journal article

Cognitive ability and metabolic physical health in first-episode psychosis

Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott

SCHIZOPHRENIA RESEARCH-COGNITION | ELSEVIER | Published : 2021

DOI: 10.1016/j.scog.2021.100194

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Abstract

Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure. Individuals with chronic psychosis experience poorer physical health while taking antipsychotic medication, but health disparities may be evident at FEP onset, prior to antipsychotic exposure. Given the links between cognition and physical health in healthy populations, the aim was to explore whether cognition and physical health are associated in FEP, which could inform early physical health interventions for cognition in FEP. Participants were aged 15 to 25 and included 86 individuals experiencing FEP with limited antipsychotic exposure and duration of untreat..

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University of Melbourne Researchers

Hok Yuen Author Centre for Youth Mental Health

Kelly Allott Author Centre for Youth Mental Health

Rob Hester Author Melbourne School of Psychological Sciences

Christos Pantelis Author Psychiatry

Melissa Kerr Author Centre for Youth Mental Health

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

The study was supported by the National Health and Medical Research Council (NHMRC) (1064704). KA is supported by a NHMRC Career Development Fellowship (1141207). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660 and 1156072). BN is supported by an NHMRC Senior Research Fellowship (1137687). CP was supported by a NHMRC Senior Principal Research Fellowship (1105825). This study has been supported by a large number of clinical staff at Orygen Youth Health: Craig Macneil, Kingsley Crisp, Dylan Alexander, Tina Proffitt, Rachel Tindall, Jennifer Hall, Lisa Rumney, Franco Scalzo, Melissa Pane, Linda Kader, Frank Hughes, Clare Shelton, Ryan Kaplan, David Hallford, Bridget Moller, Rick Fraser, and research assistants: Daniela Cagliarini, Suzanne Wiltink, Janine Ward, and Sumudu Mallawaarachichi.