Journal article

Tibolone improves depression in women through the menopause transition: A double-blind randomized controlled trial of adjunctive tibolone

Jayashri Kulkarni, Emorfia Gavrilidis, Natalie Thomas, Abdul-Rahman Hudaib, Roisin Worsley, Caroline Thew, Caitlin Bleeker, Caroline Gurvich

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2018

Abstract

BACKGROUND: Many women with no past psychiatric history experience severe mood symptoms for the first time in their life during the menopausal transition, with debilitating long-term consequences. Women with a history of depression can experience a relapse or worsening of symptoms during the menopause transition. Traditional antidepressants, SSRIs or SNRIs, are commonly prescribed as the first line response. However, such treatment has shown only small improvements with side effects. Hormone therapies directly targeting the perimenopausal fluctuations in reproductive hormonal systems such as tibolone, have significant potential to treat perimenopausal depression. Our study investigated the u..

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