Can models of percutaneous absorption based on in vitro data in frogs predict in vivo absorption?
Victoria K Llewelyn, Lee Berger, Beverley D Glass
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2020
The primary aim of in vitro testing of chemicals delivered via the percutaneous route is to predict the absorption that would ensue if exposure occurred in live animals. While there is mounting evidence that in vitro diffusion studies in mammalian skin can provide valid information regarding likely in vivo absorption, little is known whether such a correlation exists between in vitro diffusion testing and in vivo blood levels in amphibians. The current study used previously-reported in vitro absorption data for caffeine, benzoic acid, and ibuprofen across isolated skin from the cane toad (Rhinella marina) to produce a series of linear mixed-effect models of the absorption parameters flux and..View full abstract