Journal article

Oxidative Stress and the Role of NADPH Oxidase in Glaucoma

Jennifer C Fan Gaskin, Manisha H Shah, Elsa C Chan

ANTIOXIDANTS | MDPI | Published : 2021


Glaucoma is characterised by loss of retinal ganglion cells, and their axons and many pathophysiological processes are postulated to be involved. It is increasingly understood that not one pathway underlies glaucoma aetiology, but rather they occur as a continuum that ultimately results in the apoptosis of retinal ganglion cells. Oxidative stress is recognised as an important mechanism of cell death in many neurodegenerative diseases, including glaucoma. NADPH oxidase (NOX) are enzymes that are widely expressed in vascular and non-vascular cells, and they are unique in that they primarily produce reactive oxygen species (ROS). There is mounting evidence that NOX are an important source of RO..

View full abstract


Funding Acknowledgements

This study is supported by the Ophthalmic Research Institute of Australia research grant. The Centre for Eye Research Australia received Operational Infrastructure Support from the Victorian Government.