Journal article

Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity

Isaac Ssewanyana, John Rek, Isabel Rodriguez, Lindsey Wu, Emmanuel Arinaitwe, Joaniter I Nankabirwa, James G Beeson, Harriet Mayanja-Kizza, Philip J Rosenthal, Grant Dorsey, Moses R Kamya, Chris Drakeley, Bryan Greenhouse, Kevin KA Tetteh

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

Understanding how immunity to malaria is affected by declining transmission is important to aid vaccine design and understand disease resurgence. Both IgG subclasses and avidity of antigen-specific responses are important components of an effective immune response. Using a multiplex bead array assay, we measured the total IgG, IgG subclasses, and avidity profiles of responses to 18 P. falciparum blood stage antigens in samples from 160 Ugandans collected at two time points during high malaria transmission and two time points following a dramatic reduction in transmission. Results demonstrated that, for the antigens tested, (i) the rate of decay of total IgG following infection declined with ..

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Grants

Awarded by National Institutes of Health as part of the East African International Centers of Excellence in Malaria Research (ICMER) program


Awarded by Fogarty International Centre (FIC) Training in malaria research in Uganda award


Awarded by Bloomsbury SET Award


Funding Acknowledgements

This study was supported by funds from the National Institutes of Health as part of the East African International Centers of Excellence in Malaria Research (ICMER) program (U19AI089674) and a Fogarty International Centre (FIC) Training in malaria research in Uganda award (D43TW7375). Additional support was provided by a Bloomsbury SET Award (Innovation Fellowship to KKAT; BSA14) under the UKRI Connecting Capabilities Fund (CCF).