Predicting in vivo absorption of chloramphenicol in frogs using in vitro percutaneous absorption data
Victoria K Llewelyn, Lee Berger, Beverley D Glass
BMC VETERINARY RESEARCH | BMC | Published : 2021
BACKGROUND: Infectious disease, particularly the fungal disease chytridiomycosis (caused by Batrachochytrium dendrobatidis), is a primary cause of amphibian declines and extinctions worldwide. The transdermal route, although offering a simple option for drug administration in frogs, is complicated by the lack of knowledge regarding percutaneous absorption kinetics. This study builds on our previous studies in frogs, to formulate and predict the percutaneous absorption of a drug for the treatment of infectious disease in frogs. Chloramphenicol, a drug with reported efficacy in the treatment of infectious disease including Batrachochytrium dendrobatidis, was formulated with 20% v/v propylene g..View full abstract
The analytical component of this work (use of the UHPLC for analysis of serum and urine samples) was supported by a grant from the College of Medicine and Dentistry, James Cook University.