Journal article

Impact of maternal diphtheria-tetanus-acellular pertussis vaccination on pertussis booster immune responses in toddlers: Follow-up of a randomized trial

Federico Martinon-Torres, Scott A Halperin, Terry Nolan, Bruce Tapiero, Kirsten P Perrett, Ignacio Salamanca de la Cueva, Jose Garcia-Sicilia, Zbynek Stranak, Otto G Vanderkooi, Pavel Kosina, Sarka Rumlarova, Miia Virta, Jose M Merino Arribas, Mariano Miranda-Valdivieso, Begona Arias Novas, Jan Bozensky, Maria Jose Cilleruelo Ortega, Jose Tomas Ramos Amador, Manuel Baca, Esperanza Escribano Palomino Show all

VACCINE | ELSEVIER SCI LTD | Published : 2021

Abstract

BACKGROUND: Transplacentally transferred antibodies induced by maternal pertussis vaccination interfere with infant immune responses to pertussis primary vaccination. We evaluated whether this interference remains in toddlers after booster vaccination. METHODS: In a prior phase IV, observer-blind, placebo-controlled, randomized study (NCT02377349), pregnant women in Australia, Canada and Europe received intramuscular tetanus-reduced-antigen-content diphtheria-three-component acellular pertussis vaccine (Tdap group) or placebo (control group) at 270/7-366/7 weeks' gestation, with crossover immunization postpartum. Their infants were primed (study NCT02422264) and boosted (at 11-18 months; cur..

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