Journal article
Impact of maternal diphtheria-tetanus-acellular pertussis vaccination on pertussis booster immune responses in toddlers: Follow-up of a randomized trial
Federico Martinon-Torres, Scott A Halperin, Terry Nolan, Bruce Tapiero, Kirsten P Perrett, Ignacio Salamanca de la Cueva, Jose Garcia-Sicilia, Zbynek Stranak, Otto G Vanderkooi, Pavel Kosina, Sarka Rumlarova, Miia Virta, Jose M Merino Arribas, Mariano Miranda-Valdivieso, Begona Arias Novas, Jan Bozensky, Maria Jose Cilleruelo Ortega, Jose Tomas Ramos Amador, Manuel Baca, Esperanza Escribano Palomino Show all
VACCINE | ELSEVIER SCI LTD | Published : 2021
Abstract
BACKGROUND: Transplacentally transferred antibodies induced by maternal pertussis vaccination interfere with infant immune responses to pertussis primary vaccination. We evaluated whether this interference remains in toddlers after booster vaccination. METHODS: In a prior phase IV, observer-blind, placebo-controlled, randomized study (NCT02377349), pregnant women in Australia, Canada and Europe received intramuscular tetanus-reduced-antigen-content diphtheria-three-component acellular pertussis vaccine (Tdap group) or placebo (control group) at 270/7-366/7 weeks' gestation, with crossover immunization postpartum. Their infants were primed (study NCT02422264) and boosted (at 11-18 months; cur..
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Funding Acknowledgements
This work was supported by GlaxoSmithKline Biologicals S.A., which was the funding source, was involved in all stages of the study conduct and analysis and paid for all costs associated with the development and publishing of this manuscript.