Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Timon Damelang; Elizabeth H Aitken; Wina Hasang; Ester Lopez; Martin Killian; Holger W Unger; Ali Salanti; Alexis Shub; Elizabeth McCarthy; Katherine Kedzierska; Martha Lappas; Stephen J Kent; Stephen J Rogerson; Amy W Chung

Journal article

Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Timon Damelang, Elizabeth H Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J Kent, Stephen J Rogerson, Amy W Chung

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2021

DOI: 10.1038/s41598-021-83093-4

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Abstract

Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malari..

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University of Melbourne Researchers

Amy Chung Author Microbiology and Immunology

Ester Lopez Author Microbiology and Immunology

Alexis Shub Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stephen Kent Author Microbiology and Immunology

Elizabeth McCarthy Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Awarded by NHMRC Career Development Fellowship

Awarded by Bill & Melinda Gates Foundation

Awarded by NHMRC Investigator Fellowship

Funding Acknowledgements

This work was supported by a Project Grant from the National Health and Medical Research Council of Australia (NHMRC) to SJR, EHA and AWC (APP1143946) and a Program Grant (APP1092789) also from the NHMRC. AWC is supported by an NHMRC Career Development Fellowship (APP1140509). Sample collection was primarily supported by the Malaria in Pregnancy Consortium, through a Grant from the Bill & Melinda Gates Foundation (46099). AS, EM and ML were funded by the Medical Research Foundation for Women and Babies and the Mercy Research Foundation. KK is supported by an NHMRC Investigator Fellowship (1173871). KK and AWC are supported by the University of Melbourne Dame Kate Campbell Fellowship.