Journal article

Response of primary auditory neurons to stimulation with infrared light in vitro

William GA Brown, Karina Needham, James M Begeng, Alexander C Thompson, Bryony A Nayagam, Tatiana Kameneva, Paul R Stoddart

Journal of Neural Engineering | IOP PUBLISHING LTD | Published : 2021

Abstract

Objective.Infrared light can be used to modulate the activity of neuronal cells through thermally-evoked capacitive currents and thermosensitive ion channel modulation. The infrared power threshold for action potentials has previously been found to be far lower in thein vivocochlea when compared with other neuronal targets, implicating spiral ganglion neurons (SGNs) as a potential target for infrared auditory prostheses. However, conflicting experimental evidence suggests that this low threshold may arise from an intermediary mechanism other than direct SGN stimulation, potentially involving residual hair cell activity.Approach.Patch-clamp recordings from cultured SGNs were used to explicitl..

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Grants

Awarded by Australian Research Council Linkage Project


Funding Acknowledgements

We thank Helen Q Cai (Royal Victorian Eye and Ear Hospital, University of Melbourne) for the TRPV1 immunostaining figure in supplementary figure S3. This work was part funded by the Australian Research Council Linkage Project (LP120100264). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.