Clinical applications of omega-3 fatty acids for corneal and peripheral nerve health

Abstract

Peripheral neuropathy, a common complication of diabetes, can lead to debilitating functional impairment and adversely impact daily living. In diabetes, damage to small sensory nerves in the cornea, visible using in vivo confocal microscopy (IVCM), precedes large nerve fibre involvement. Quantitative corneal nerve parameters, derived from IVCM images, provide reliable markers for evaluating small fibre damage and repair in diabetic peripheral neuropathy. A current challenge in the management of diabetic peripheral neuropathy is a lack of effective treatments. Omega-3 polyunsaturated fatty acids (PUFAs) modulate systemic inflammation and impart neurotrophic effects and, thus, show promise as ..