Journal article

Clinical and Molecular Epidemiology of an Emerging Panton-Valentine Leukocidin-Positive ST5 Methicillin-Resistant Staphylococcus aureus Clone in Northern Australia

Sarah L McGuinness, Deborah C Holt, Tegan M Harris, Connor Wright, Rob Baird, Phillip M Giffard, Asha C Bowen, Steven YC Tong



Recently, we identified a Staphylococcus aureus sequence type 5 (ST5) clone in northern Australia with discrepant trimethoprim-sulfamethoxazole (SXT) susceptibility results. We aimed to identify isolates of this clone using Vitek 2 SXT resistance as a proxy and to compare its epidemiology with those of other circulating S. aureus strains. We collated Vitek 2 susceptibility data for S. aureus isolates collected through our laboratory and conducted a prospective, case-control study comparing clinical, microbiological, epidemiological, and genomic data for subsets of isolates reported as SXT resistant (cases) and SXT susceptible (controls) by Vitek 2. While overall SXT resistance rates remained..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council of Australia (NHMRC) Postgraduate Scholarship

Awarded by NHMRC Career Development and Early Career Fellowships

Funding Acknowledgements

We thank the microbiology laboratory staff at the Royal Darwin Hospital for their assistance in collecting S. aureus isolates for genotyping. We also thank Judith Wilson, Kerrie Cleanthous, and Julius Franssen for technical assistance. No specific funding was provided for this study. S.L.M. (1115196) is supported by a National Health and Medical Research Council of Australia (NHMRC) Postgraduate Scholarship. S.Y.C.T. (1065736) and A.C.B. (1088735) are supported by NHMRC Career Development and Early Career Fellowships, respectively. All authors have no conflicts of interest to declare.