Journal article

Investigating the brain structural connectome following working memory training in children born extremely preterm or extremely low birth weight

Claire E Kelly, Rebecca Harding, Katherine J Lee, Leona Pascoe, Elisha K Josev, Megan M Spencer-Smith, Chris Adamson, Richard Beare, Chiara Nosarti, Gehan Roberts, Lex W Doyle, Marc L Seal, Deanne K Thompson, Peter J Anderson



Children born extremely preterm (EP, <28 weeks' gestation) or extremely low birth weight (ELBW, <1,000 g) are a vulnerable population at high risk of working memory impairments. We aimed to examine changes in the brain structural connectivity networks thought to underlie working memory performance, after completion of a working memory training program (Cogmed) compared with a placebo program in EP/ELBW children. This was a double-blind, placebo-controlled randomized trial (the Improving Memory in a Preterm Randomised Intervention Trial). Children born EP/ELBW received either the Cogmed or placebo program at 7 years of age (n = 91). A subset of children had magnetic resonance imaging of the b..

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Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

Australian National Health and Medical Research Council, Grant/Award Number: 1028422, 1060733, 606789, 1081288, 1085754, 1127984 and 1160003; The Murdoch Children's Research Institute, The Royal Children's Hospital, The Royal Children's Hospital Foundation; The Department of Paediatrics at The University of Melbourne, Monash University; the Victorian Government's Operational Infrastructure Support Program