Journal article

Interictal spike localization for epilepsy surgery using magnetoencephalography beamforming

Rui Li, Chris Plummer, Simon J Vogrin, William P Woods, Levin Kuhlmann, Ray Boston, David TJ Liley, Mark J Cook, David B Grayden



OBJECTIVE: Magnetoencephalography (MEG) kurtosis beamforming is an automated localization method for focal epilepsy. Visual examination of virtual sensors, which are source activities reconstructed by beamforming, can improve performance but can be time-consuming for neurophysiologists. We propose a framework to automate the method and evaluate its effectiveness against surgical resections and outcomes. METHODS: We retrospectively analyzed MEG recordings of 13 epilepsy surgery patients who had one-year minimum post-operative follow-up. Kurtosis beamforming was applied and manual inspection was confined to morphological clusters. The region with the Maximum Interictal Spike Frequency (MISF) w..

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Funding Acknowledgements

The authors acknowledge Associate Professor Michael A. Murphy, who performed resection surgeries. The authors acknowledge the facilities and the scientific and technical assistance of the National Imaging Facility at the Swinburne Node, Swinburne University of Technology, with particular thanks to Dr Rachel Batty, Ms Mahla Cameron-Bradley, and Ms Johanna Stephens for their technical support. We acknowledge the Australian National Imaging Facility for the support of W. Woods and the MEG system at Swinburne University of Technology.