Journal article

Mechanisms of regulate gene expression during immune cell differentiation and development Conversations that count: Cellular interactions that drive T cell fate

Brigette C Duckworth, Joanna R Groom



The relationship between the extrinsic environment and the internal transcriptional network is circular. Naive T cells first engage with antigen-presenting cells to set transcriptional differentiation networks in motion. In turn, this regulates specific chemokine receptors that direct migration into distinct lymph node niches. Movement into these regions brings newly activated T cells into contact with accessory cells and cytokines that reinforce the differentiation programming to specify T cell function. We and others have observed similarities in the transcriptional networks that specify both CD4+ T follicular helper (TFH ) cells and CD8+ central memory stem-like (TSCM ) cells. Here, we co..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: GNT1137989 and GNT1182649; Australian Research Council, Grant/Award Number: 130100708; Walter and Eliza Hall Centenary Fellowship